Nebenwirkungen arcoxia 90mg - Packungsgrößen
arcoxia filmtabletten 90mg nebenwirkungen. Herzinfarktes, arcoxia 90 mg kaufen ohne rezept nach Ã bernehmen selbstverst ndlich berichtet die türzarge eingebaut.
Qualitative and quantitative composition Each film-coated tablet contains 30, 60, 90 or mg of etoricoxib.
Excipients with known effect: Pharmaceutical form Film-coated tablets tablets. Blue-green, apple-shaped biconvex tablets debossed '' on one side and 'ACX 30' on the other side. ARCOXIA is indicated in adults and adolescents 16 years of age and older for the short-term treatment of moderate pain associated with dental surgery. The decision to prescribe a selective COX-2 inhibitor should 90mg based on an assessment of the individual patient's overall risks see sections 4.
The patient's escitalopram for panic disorder for symptomatic relief and response to therapy should be re-evaluated periodically, especially in patients with osteoarthritis see sections 4.
90mg The recommended dose is 30 mg once daily. In some patients with insufficient relief from symptoms, an increased dose of 90mg mg once daily may increase efficacy. In the absence of an increase in therapeutic benefit, other nebenwirkungen options should be arcoxia.
Rheumatoid arthritis The recommended dose is 60 mg once daily. In some patients with insufficient relief from symptoms, an increased dose of 90 mg once daily may increase efficacy. Once the patient is arcoxia stabilised, down-titration to a 60 mg once arcoxia dose may be appropriate.
Ankylosing spondylitis The recommended dose is 60 mg once daily. Acute pain conditions For acute pain conditions, etoricoxib should be used only for the acute symptomatic period. Acute gouty arthritis The recommended dose is mg once daily. In clinical trials for acute gouty arthritis, nebenwirkungen arcoxia 90mg, etoricoxib was given for 8 days, nebenwirkungen arcoxia 90mg. Postoperative dental surgery pain The recommended dose is 90 mg once daily, limited to a maximum of 3 days.
Doses greater nebenwirkungen those recommended for each indication have either not demonstrated additional efficacy or have not been studied. The dose for OA should not exceed 60 mg daily. The dose for RA and ankylosing spondylitis should not exceed 90 mg daily. The dose for acute gout should not exceed mg daily, limited to a maximum of 8 days treatment, nebenwirkungen arcoxia 90mg.
The dose for postoperative acute dental surgery pain should not exceed 90 mg daily, limited to a maximum of 3 days. 90mg populations Nebenwirkungen patients No dosage adjustment is necessary nebenwirkungen elderly patients. As with other drugs, caution should arcoxia exercised in elderly patients see section 4, nebenwirkungen arcoxia 90mg.
Patients with hepatic impairment Regardless of indication, in patients with mild hepatic dysfunction Child-Pugh score a dose of 60 mg once daily should not be exceeded. In patients with moderate arcoxia dysfunction Child-Pugh scoreregardless of indication, the dose of nebenwirkungen mg once daily should not be exceeded. Clinical experience arcoxia limited particularly in patients with moderate hepatic dysfunction and caution is advised.
Paediatric population Etoricoxib is contra-indicated in children and adolescents under 16 years of age see section 4. This should be considered when rapid symptomatic relief is needed.
Caution is advised with treatment of nebenwirkungen most at risk of developing a gastrointestinal complication with NSAIDs; the elderly, nebenwirkungen arcoxia 90mg, patients using 90mg other NSAID or acetylsalicylic acid concomitantly arcoxia patients with 90mg prior history of gastrointestinal disease, such as ulceration and GI bleeding.
There is a further increase in the risk nebenwirkungen gastrointestinal adverse effects gastrointestinal ulceration or other gastrointestinal complications when etoricoxib is taken concomitantly with acetylsalicylic acid even at low doses.
90mg effects Clinical trials suggest that the selective COX-2 inhibitor class of drugs may be associated with a risk of thrombotic events especially myocardial infarction MI and strokerelative to placebo and some NSAIDs. As the cardiovascular risks of etoricoxib may increase with dose and duration of exposure, the shortest duration possible and the lowest effective daily dose should be used.
Patients with significant risk factors for cardiovascular events e. COX-2 selective inhibitors are not a substitute for acetylsalicylic acid for nebenwirkungen of cardiovascular thrombo-embolic diseases because of their lack of antiplatelet effect.
Therefore antiplatelet therapies should nebenwirkungen be discontinued see sections above, 4. Renal effects Renal prostaglandins may play a compensatory role in the maintenance of renal perfusion. Therefore, under conditions of compromised renal perfusion, administration of etoricoxib may cause a reduction 90mg prostaglandin arcoxia and, secondarily, in renal blood flow, nebenwirkungen arcoxia 90mg, 90mg thereby impair arcoxia function.
Patients at greatest risk of this response are those with arcoxia significantly impaired renal function, uncompensated heart failure, or cirrhosis. Monitoring of renal function in such patients should be 90mg. Fluid retention, oedema and hypertension As with other medicinal products known to inhibit prostaglandin synthesis, fluid retention, oedema and hypertension have been observed in patients taking etoricoxib.
For information regarding a dose related response for etoricoxib nebenwirkungen section 5.
Caution should be exercised in patients with a history of cardiac failure, left ventricular dysfunction, nebenwirkungen arcoxia 90mg, or hypertension and in patients with pre-existing oedema from any other reason.
If there is clinical evidence arcoxia deterioration in the condition of these patients, appropriate measures including discontinuation of etoricoxib should be taken. Etoricoxib may be associated with more frequent and severe hypertension than some other NSAIDs and selective Nebenwirkungen inhibitors, particularly at high doses.
Therefore, hypertension should be controlled before treatment with etoricoxib see section 4. Blood pressure should be monitored within two weeks after initiation of treatment and periodically thereafter. If blood pressure rises significantly, alternative treatment 90mg be considered. If signs of hepatic insufficiency occur, or if persistently abnormal liver function tests three times the upper limit of normal are detected, nebenwirkungen arcoxia 90mg, etoricoxib should be discontinued.
keine Nebenwirkungen bei ARCOXIA
General If 90mg treatment, patients deteriorate in any of the organ system functions described above, appropriate measures arcoxia be taken and discontinuation of etoricoxib therapy should be considered.
Medically appropriate supervision should be maintained when using etoricoxib in the elderly and in patients with renal, hepatic, or cardiac dysfunction. Caution should be used when initiating treatment with oxycodone no prescription cheap in patients with dehydration, nebenwirkungen arcoxia 90mg. It is advisable to rehydrate patients prior to starting therapy with etoricoxib. Serious skin reactions, some of them fatal, including exfoliative dermatitis, nebenwirkungen arcoxia 90mg, Stevens-Johnson syndrome, and toxic epidermal necrolysis, have been reported very rarely in association with the use of NSAIDs nebenwirkungen some selective COX-2 inhibitors during post-marketing surveillance see section 4.
Patients appear to be at highest risk for these seroquel anxiety disorders early in the course of therapy with the onset of the reaction occurring in the majority of cases within the first month of treatment, nebenwirkungen arcoxia 90mg. Serious hypersensitivity reactions such as anaphylaxis and angioedema have been reported in patients receiving etoricoxib see section 4.
Some selective COX-2 inhibitors have been associated with an increased risk of skin reactions in patients with a history of any drug allergy. Etoricoxib should be discontinued at the first appearance of skin rash, mucosal lesions, or any other sign of hypersensitivity. Etoricoxib may mask fever and other signs of inflammation, nebenwirkungen arcoxia 90mg. Caution should be exercised when co-administering etoricoxib with warfarin or other 90mg anticoagulants see section nebenwirkungen. Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.
Therefore, patients receiving oral anticoagulants should be closely monitored arcoxia their prothrombin time INR, particularly in the first few days when therapy with etoricoxib is initiated or the dose of etoricoxib is changed see section 4. NSAIDs may reduce the effect of diuretics nebenwirkungen other antihypertensive drugs.
In some patients with compromised renal function e. These interactions should be considered in patients taking etoricoxib concomitantly with ACE inhibitors or angiotensin II antagonists. Therefore, nebenwirkungen combination should be administered with caution, especially in the elderly. Patients should be adequately hydrated and consideration should be given to monitoring of renal function after initiation of concomitant therapy, and periodically thereafter.
In a study in healthy subjects, at steady state, etoricoxib mg once daily had no effect on the anti-platelet activity of acetylsalicylic acid 81 mg once daily. Etoricoxib can be used concomitantly with acetylsalicylic acid at doses used for cardiovascular prophylaxis low-dose acetylsalicylic acid. However, concomitant administration of low-dose acetylsalicylic acid with etoricoxib may result in an increased rate of GI ulceration or other complications compared to use of etoricoxib alone, nebenwirkungen arcoxia 90mg.
Concomitant administration of etoricoxib with doses of acetylsalicylic acid above those for cardiovascular prophylaxis or with other NSAIDs is not recommended see sections 5, nebenwirkungen arcoxia 90mg. Although this interaction has not been studied with etoricoxib, coadministration of cyclosporin or tacrolimus with any NSAID may increase the nephrotoxic effect of cyclosporin or tacrolimus. Renal function should be monitored when etoricoxib and either of these drugs is used in combination.
Pharmacokinetic interactions The effect of etoricoxib on the pharmacokinetics of other drugs Lithium: NSAIDs decrease lithium renal excretion and therefore increase lithium plasma levels. If necessary, monitor blood lithium closely and adjust the lithium dosage while the combination is being taken and when the NSAID is withdrawn. Two studies investigated the effects of etoricoxib 60, 90 or mg arcoxia once daily for 90mg days in patients receiving once-weekly methotrexate doses of 7.
Etoricoxib at 60 and 90 mg had no effect on methotrexate plasma concentrations or nebenwirkungen clearance. Adequate monitoring for methotrexate-related toxicity is recommended when etoricoxib and methotrexate are administered concomitantly, nebenwirkungen arcoxia 90mg. Nebenwirkungen 60 mg given concomitantly with an oral contraceptive containing 35 micrograms ethinyl estradiol EE and 0, nebenwirkungen arcoxia 90mg. This increase in EE concentration should be considered nebenwirkungen selecting an oral contraceptive for use with etoricoxib.
An increase in EE exposure can increase the incidence of adverse events associated with oral contraceptives e. Administration of etoricoxib mg with hormone replacement therapy consisting arcoxia conjugated estrogens 0. The effect of the recommended chronic doses of etoricoxib 30, nebenwirkungen arcoxia 90mg, 60, and 90 mg has not been studied. These increases in estrogenic concentration should be taken into consideration when selecting post-menopausal hormone therapy for use with etoricoxib because the increase in 90mg exposure might increase the risk of adverse events associated with HRT.
Etoricoxib mg administered once daily for 10 days to healthy volunteers did not alter the steady-state plasma AUChr or renal elimination of digoxin. This increase is not generally important for most patients, nebenwirkungen arcoxia 90mg. However, patients at high risk of digoxin toxicity should be 90mg for this when etoricoxib and digoxin are administered concomitantly.
Effect of etoricoxib on drugs metabolised by sulfotransferases Etoricoxib is an inhibitor of human sulfotransferase activity, particularly SULT1E1, and has been shown to increase the serum concentrations of ethinyl estradiol.
While knowledge about effects of multiple sulfotransferases is presently limited and the clinical consequences for many drugs are still being 90mg, it may be prudent to exercise nebenwirkungen when administering etoricoxib concurrently with arcoxia drugs primarily metabolised by human sulfotransferases e.
In a study in healthy subjects, daily administration of etoricoxib mg did not alter arcoxia CYP3A4 activity as assessed by the erythromycin breath test. Effects of other drugs on the pharmacokinetics of etoricoxib The main pathway of etoricoxib metabolism is dependent on CYP enzymes. CYP3A4 arcoxia to contribute to the metabolism of etoricoxib in vivo, nebenwirkungen arcoxia 90mg.
Co-administration of either oral voriconazole or topical miconazole nebenwirkungen gel, strong CYP3A4 inhibitors, with etoricoxib caused a slight increase in exposure to etoricoxib, but is not 90mg to be clinically 90mg based on published data. This interaction may arcoxia in recurrence of symptoms when etoricoxib is co-administered canadian online pharmacy phentermine rifampicin.
While this cialis online norge may suggest an increase in dose, doses of etoricoxib greater than arcoxia listed for each indication have not been studied in combination with rifampicin and are therefore not recommended see section 4, nebenwirkungen arcoxia 90mg.
Antacids do not affect the pharmacokinetics of etoricoxib to a clinically relevant extent, nebenwirkungen arcoxia 90mg. Studies in animals have shown reproductive toxicity see section 5.