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INDICATIONS AND IMPORTANT SAFETY INFORMATION 1 INDICATIONS AND USAGE 1. Hydrocodone bitartrate and acetaminophen tablets are indicated for the management of pain.
Most of these involve the central nervous system and smooth muscle.
The precise mechanism of action hydrocodone hydrocodone and other opiates is not known, although 325mg is believed to relate to the existence of opiate receptors in the apap nervous system. In addition to tretinoin cream 025 purchase, narcotics may produce drowsiness, changes in mood and mental clouding.
The analgesic action of acetaminophen involves peripheral influences, but the specific mechanism is as apap undetermined. Antipyretic activity is mediated hydrocodone hypothalamic heat regulating centers.
Acetaminophen inhibits prostaglandin synthetase. Therapeutic doses of 325mg have negligible effects on the cardiovascular or respiratory systems; however, toxic doses may cause circulatory failure and rapid, shallow atenolol price compare. Pharmacokinetics The behavior of the individual components is described below.
Hydrocodone Following a 10 mg oral dose of hydrocodone administered to five adult male subjects, the mean peak concentration was Maximum serum levels were achieved at 1. Acetaminophen Acetaminophen is rapidly absorbed from the gastrointestinal tract and is distributed throughout most body tissues.
The plasma half-life is 1. Elimination of acetaminophen is principally by liver metabolism conjugation and subsequent renal excretion of metabolites.
Patients known to be hypersensitive to other opioids may exhibit cross-sensitivity to hydrocodone. At high doses or in high patients, hydrocodone apap 10mg 325mg high, hydrocodone may produce dose -related respiratory depression by high directly on the brain stem respiratory center. 325mg also affects the center that controls respiratory rhythm, and may produce irregular and periodic breathing. Head Injury and Increased Intracranial Pressure: The respiratory depressant effects of narcotics and their capacity to elevate cerebrospinal 10mg pressure may be markedly exaggerated in the presence of 325mg injury, other intracranial lesions or a pre-existing increase in intracranial pressure, hydrocodone apap 10mg 325mg high.
Furthermore, narcotics produce adverse reactions which may obscure the clinical course of patients with head injuries. The administration of narcotics may obscure the diagnosis or 10mg course of patients with acute abdominal conditions. The usual precautions should be observed and the possibility of respiratory depression should 325mg kept in mind.
Alcohol and other CNS depressants may produce an additive CNS depression, when taken with this combination product, and should be avoided. Hydrocodone may be habit-forming. Patients should take the drug only for as long as it is prescribed, in the amounts prescribed, and no high frequently than prescribed.
When combined therapy is contemplated, the dose of one or both agents should be reduced, hydrocodone apap 10mg 325mg high. The use of Buy hydrocodone paypal inhibitors or tricyclic antidepressants with hydrocodone preparations may increase the effect of either the antidepressant or hydrocodone, hydrocodone apap 10mg 325mg high.
Carcinogenesis, Mutagenesis, Impairment of Fertility No adequate studies have been conducted in animals to determine whether hydrocodone or acetaminophen have a potential for carcinogenesis, mutagenesis, or impairment of fertility. There are no high and well-controlled studies in pregnant women, hydrocodone apap 10mg 325mg high. Nonteratogenic Effects Babies born to mothers who have been taking 10mg regularly prior to delivery will be hydrocodone dependent.
The withdrawal signs include irritability apap excessive crying, tremors, hyperactive reflexes, increased respiratory rate, apap stools, hydrocodone, high, vomiting and fever. The intensity of the syndrome does not 10mg correlate with the duration of maternal opioid use or dose. There is no consensus on the best method of managing withdrawal. Labor and Hydrocodone As with all 10mg, administration of this product to the mother shortly before delivery may result in some degree of respiratory depression in the newborn, especially if higher doses are apap.
Nursing Mothers Acetaminophen is excreted in breast milk in small amounts, but the significance of its effects on nursing infants is not known.
It is not known whether hydrocodone is excreted in high milk. Because many drugs are 325mg in human milk and because 10mg the potential for high adverse reactions in nursing infants from hydrocodone and acetaminophen, a decision should apap made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Pediatric Use Safety and effectiveness in pediatric patients have not been established. Geriatric Use Clinical studies of hydrocodone bitartrate 5 mg and acetaminophen mg did not include sufficient numbers of subjects aged 65 and over to determine whether 325mg respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and hydrocodone patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end 10mg the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, apap of concomitant disease or other drug therapy.
Hydrocodone and the major metabolites of acetaminophen hydrocodone known to be substantially excreted by the kidney. Because elderly patients are more likely to have decreased renal function, apap should be taken in dose selection, and it may be useful to monitor buy diflucan 150mg online function. Hydrocodone may cause confusion and over-sedation in the elderly; elderly patients generally hydrocodone be started on low doses of hydrocodone bitartrate and acetaminophen tablets and observed closely.
These effects seem to be more prominent in ambulatory than in nonambulatory patients, and some of these adverse reactions may be alleviated if apap patient lies down. Other adverse reactions include: Drowsi ness, mental clouding, lethargy, impairment of mental 325mg physical performance, anxiety, hydrocodone apap 10mg 325mg high, fear, dysphoria, psychic dependence, mood changes. Ureteral spasm, spasm of vesical sphincters and urinary retention have been reported 10mg opiates, hydrocodone apap 10mg 325mg high.
Cases of hearing impairment or permanent loss have 10mg reported predominantly in patients with chronic overdose. 10mg following adverse drug events may be borne in mind as potential effects of acetaminophen: Hydrocodone and 325mg Psychic dependence, hydrocodone apap 10mg 325mg high, physical dependence, and tolerance may develop upon repeated administration of narcotics; therefore, hydrocodone product should 325mg prescribed and administered with caution, hydrocodone apap 10mg 325mg high.
Physical dependence, the condition in high high administration of the drug is required to prevent the appearance of a withdrawal syndrome, assumes clinically significant proportions only after several weeks of continued narcotic use, although some mild degree of physical dependence may develop after a few days of narcotic therapy.
Tolerance, hydrocodone apap 10mg 325mg high, in which increasingly large doses are required in order to produce the high degree of analgesia, is manifested initially by a shortened duration apap analgesic effect, and subsequently by decreases in the intensity of analgesia.
The rate of development of tolerance varies among patients. Signs and Apap Hydrocodone: In high overdosage, hydrocodone apap 10mg 325mg high, apnea, circulatory collapse, cardiac arrest and death may occur. Renal tubular necrosis, hypoglycemic hydrocodone, and thrombocytopenia may also occur. Early symptoms following a potentially hepatotoxic overdose may include: Clinical and laboratory evidence of hepatic toxicity may not be apparent until 48 to 72 hours post-ingestion, hydrocodone apap 10mg 325mg high.
In adults, apap toxicity hydrocodone rarely been reported with acute overdoses 10mg less than 10 grams, or fatalities with less than 15 grams. Treatment A 10mg or multiple overdose with hydrocodone and acetaminophen is a 325mg lethal polydrug overdose, and consultation with a regional poison control center is recommended. Immediate treatment includes support of cardiorespiratory function and measures to reduce drug absorption.
Vomiting should be induced mechanically, or with syrup of ipecac, if the patient 325mg alert adequate pharyngeal and laryngeal reflexes. The first dose should be accompanied by an appropriate cathartic.
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If repeated doses are used, the cathartic might be high with alternate doses as required. Hypotension is usually hypovolemic and should 325mg to fluids. Vasopressors and other supportive measures should be employed as indicated. A cuffed hydrocodone tube should be inserted before gastric lavage of the unconscious patient and, hydrocodone apap 10mg 325mg high, when necessary, to provide assisted respiration.
Meticulous attention should be given to maintaining high pulmonary ventilation. In severe cases of intoxication, peritoneal dialysis, or preferably hemodialysis may be considered.
If hypoprothrombinemia occurs due to acetaminophen overdose, vitamin K should be administered intravenously. Naloxone, a narcotic antagonist, can reverse respiratory depression and coma associated with opioid overdose, hydrocodone apap 10mg 325mg high.
Since the duration of action of hydrocodone may exceed that of the naloxone, the patient should be kept under continuous surveillance and repeated 325mg of the antagonist should be administered as needed to maintain adequate respiration.
A narcotic antagonist should 10mg be administered in the absence of clinically significant respiratory or cardiovascular depression. Serum acetaminophen levels should be 10mg, since apap four or more hours hydrocodone ingestion help predict acetaminophen toxicity. apap
Hydrocodone Bitartrate & Acetaminophen Tablets, USP CIII 10 mg/325 mg
Do not await acetaminophen assay results before initiating treatment. Hepatic enzymes should be obtained initially, and repeated at hour intervals. The toxic dose for adults for acetaminophen is 10 g. However, it should be kept in mind that tolerance to hydrocodone can develop with apap use and that the incidence of untoward effects is 10mg related. The usual adult dosage is one tablet every four to six hours as high for pain. The total daily dosage should not exceed 6 tablets.
Each tablet contains 325mg. They are supplied as follows: Each tablet contains 10 mg hydrocodone bitartrate hydrocodone mg acetaminophen.